Purified Anti-Mouse CD122 Antibody[TM-Beta 1], Functional Grade (AN004180)
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For research use only.
| Alternate Names | IL15RB, Interleukin-15 receptor subunit beta, p75, CD122, High affinity IL-2 receptor subunit beta, IL15Rbeta, IL-15Rbeta, IL-2 receptor subunit beta, Il-2/15Rbeta, IL-2R subunit beta, IL-2RB, Il-2Rbeta, Interleukin-2 receptor subunit beta, p70, p70-75, Il2rb, IL-2R&, beta |
| Clone | |
| Verified Samples | Verified Samples in FCM: C57/BL6 Mouse splenocytes |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume;Depletion Reported in the literature |
| Background | CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The TM-β1 antibody does inhibit IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Immunogen | Recombinant Mouse CD122 protein |
| Abbre | CD122 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Rat IgG2b, κ |
| Isotype Control | Purified Rat IgG2b, κ Isotype Control[LTF-2], Functional Grade |
| Applications |
FCM;Depletion
|
| Cellular Localization |
Cell membrane, Cell surface
|
| Tissue Specificity |
Expressed in peripheral lymph node and 57 other cell types or tissues.
|
| Concentration |
≥ 3 mg/mL
|
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Application References | Hanna Brauner, et al. Immunol Cell Biol. 2016 Feb;94(2):177-84. |
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